منابع مشابه
Structural domains in RNAi.
Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double-stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two related functions, highlighting models of Dros...
متن کاملPIN domains in nonsense-mediated mRNA decay and RNAi
Eukaryotic cells possess a quality control process, 'nonsense-mediated mRNA decay' (NMD) for removing aberrant mRNAs that contain nonsense mutations in their protein coding regions [1,2]. A second RNA surveillance mechanism is RNA interference (RNAi), which is thought to be an ancient pathway for the removal of foreign, in particular viral, mRNA [3,4]. Both of these processes involve turnover o...
متن کاملIdentifying structural domains in proteins.
Analysis of protein structures typically beginswith decomposition of the structure intomore basic units called structural domains. The underlying goal is to reduce a complex protein structure to a set of simpler, yet structurallymeaningful units, each ofwhich can be analyzed independently. Structural semi-independence of domains is their hallmark: domains often have compact structure that can f...
متن کاملDeclarative Bias for Structural Domains
We present a formal solution to the problem of situation identification in learning of structural concepts. Structural concepts are characterized by the interrelationships and attributes of their parts, rather than by just their own direct attributes. Our solution extends the declarative approach to bias of (Russell and Grosof, 1987) by formalizing the beliefs about relevancy in a more complex ...
متن کاملStructural Learning in Object Oriented Domains
When constructing a Bayesian network, it can be advantageous to employ structural learning algorithms to combine knowledge captured in databases with prior information provided by domain experts. Unfortunately, conventional algorithms do not exploit the occurrence of repetitive structures, which are often found in object oriented domains such as fault prediction in computer networks and large p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 2005
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2005.07.072